| Customization: | Available |
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| Powder: | Yes |
| Customized: | Customized |
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Autologous chondrocyte implantation (ACI/Autologous chondrocyte implantation) is a method used to treat joint cartilage injury and prevent the onset of post-traumatic osteoarthritis. It has been proven to alleviate pain and promote the recovery of mobility. Typically, ACI involves harvesting cartilage, isolating chondrocytes, expanding cells in vitro, and re implanting in articular cartilage defects. In order to collect a sufficient number of cells for implantation, isolated chondrocytes are typically extensively expanded from 100000 to 200000 to 40 to 60 million. During this period, the cultured chondrocytes gradually lose their proliferative ability and potential to produce cartilage specific matrix, a phenomenon known as dedifferentiation. In addition, the number of senescent cells also increases with the passage of culture time, leading to loss of division ability, loss of resistance to cell apoptosis, and acquisition of a powerful pro-inflammatory secretion group, namely the senescence related secretion phenotype (SASP).
Therefore, selective removal of aging cells from chondrocytes is crucial for ensuring the quality of ACI cells. FOXO4 DRI is a peptide antagonist designed to interfere with the interaction between FOXO4 and p53. Disrupting the interaction between p53 and FOXO4 leads to p53 being excluded from the nucleus and guided into mitochondria to induce apoptosis in senescent cells, ultimately eliminating senescent fibroblasts by triggering apoptosis.
Q1: About the after-sale service of products
A: After purchasing the products from our factory, we have A professional technical team and after-sales team to serve you and solve all your problems in the future
Q2: Can I get some samples?
A: Yes, we can provide samples, but the customer will pay the freight.
Q3: How do I start paying?
Payment can be made by Bitcoin,wire transfer or Western Union or paypal
Q4: How to confirm product quality before placing an order?
A: You can get free samples of some products. You just have to pay the shipping fee or arrange for the sample to be sent to us by express.
You can send us your product specifications and requirements and we will produce products according to your requirements.
Q5: What is your MOQ?
A: The minimum quantity we can order is 1kg.
But usually we can accept a smaller quantity, say 100g, at the cost of 100% sample charge.
Q6: Shipping Time?
A: We ship the parcel out in 3-7 days and offer tracking No.. Shipping time is different to different country. Please consult.
Welcome to be our distinguished customer, please do not hesitate to contact us!
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