Tanning is very popular in today's society and is associated with a healthy and happy image. People only need to look at billboards or popular TV series to see the ideal tanning physique related to health and reputation. However, this is not always the case. A tanned skin tone was a fashion trend of two-thirds in the late 20th century. In the 19th century, tanned skin was associated with field workers and the working class. The pale skin of the middle class and nobility is consistent with their socio-economic status and social activities. In the 20th century, this situation reversed, and those who did not tan were those who could not afford their holidays. The darker your skin, the longer it takes to tan, the better. The gossip magazine showcased influential figures of the time, with antique bronze skin, enjoying a long vacation on the idyllic beach. This is naturally reflected in the increasing tourism industry among the general public towards sunny destinations. Over the years, scientific progress has shown how harmful this fashion can be, as it can lead to photoaging and an increase in different types of skin cancer. Therefore, people from all walks of life who are unwilling to give up their long-awaited tanning effects are seeking alternative methods to achieve this goal. In this issue, Dr. Hueso and his colleagues reported a case of illegal use of a substance to increase melanin production. In this article, I will focus on introducing the drug Melanotan.
What is Melanotan?
Melanotan is α- Melanocyte stimulating hormone( α- Synthetic analogues of MSH, α- MSH is a hormone belonging to the melanocortin peptide hormone class, which has different functions in the body. one α- MSH binds to different melanocortin receptors to produce different effects, including the following:
one
By binding to the melanin 1 receptor (MC1R), the production of melanin is increased, thereby stimulating the production of various enzymes including tyrosinase. It seems to also stimulate the proliferation of melanocytes. 1-3
two
By binding with MC3R in the central nervous system, it produces erections and increases sexual desire. Unlike Sildenaf (a phosphodiesterase 5 inhibitor that produces erections through peripheral action), it does not require sexual stimulation and has a more long-lasting effect. four
three
Decreased appetite. The effect of inhibiting appetite is caused by the central binding of hormones to MC4R and the peripheral binding to MC2R. It seems that it may also affect fat breakdown by binding with MC5R. four
four
Immunomodulatory effects. It seems to reduce inflammation and immune responses in the body. four
five
Vascular vasopressors have an impact on the cardiovascular system, leading to an increase in blood pressure. four
six
Behavior change. The impact in this area varies greatly, in addition to changing sexual and dietary behaviors, it may also affect learning, attention, and motor coordination. four
Comments and testing reports
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