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Humanin is a peptide widely present in animal bodies and born in mitochondria. It is conserved in animals and has neuroprotective and cellular effects.
Recently, scientists have confirmed that Humanin peptides can prolong lifespan and reduce the risk of age-related diseases such as Alzheimer's disease, which is crucial for regulating the physical health and lifespan of animals and humans. In many species, the level of Humanin peptides decreases with age.
Pinchas Cohen and others from the University of Southern California in the United States published a research paper titled "The mitochondrial derived peptide human is a regulator of lifespan and healthspan" in Aging, revealing the magic of this mitochondrial peptide.
After discovering that Humanin peptides can extend the lifespan of worms, researchers examined whether human hormone therapy starting in middle age can prolong the lifespan of mice. Applying HNG to these female mice does not prolong their lifespan, but it can improve metabolic parameters without altering food intake.
The research team found that overexpression of human in Caenorhabditis elegans can effectively prolong lifespan, which depends on the daf-16/Foxo signaling pathway.
Humanin transgenic mice have many phenotypes that overlap with worm phenotypes, and similar to exogenous human treatment, their protective effect against toxic damage is enhanced.
Twice a week, researchers treated middle-aged mice with a potent Humanin peptide analogue, HNG, which improved metabolic health range parameters and reduced inflammatory markers.
In various species, human protein levels typically decrease with age. But this study shows that the aging model of naked mole mice can be ignored, and the levels of human in their bodies are surprisingly stable. The naked mole has always been a long-lived species used for aging research, with a lifespan of up to 30 years -10 times that of other rodent species.
In addition, researchers have also observed similar results in the offspring of centenarians. They are more likely to become centenarians, with significantly higher levels of Humanin peptides in their circulating serum compared to age matched control subjects. Afterwards, researchers also observed a decrease in Humanin peptide levels in patients with human diseases such as Alzheimer's disease and MELAS (mitochondrial encephalopathy, lactic acidosis, and stroke like attacks). In summary, these studies have demonstrated for the first time that Humanin peptides are associated with improving health conditions and extending lifespan.
Magical Humanin Peptides
Mitochondria are at the center of the aging theory, as they are the main producers of energy and free radicals, regulating cell apoptosis, and their dysfunction is the key to the physiological decline observed during the aging process. Similarly, mitochondrial dysfunction has been found in many age-related diseases, although it is a causal or simple correlation.
In addition, in addition to their roles in energy utilization and cell survival, changes in mitochondrial genes can also increase the lifespan of several model organisms, and mitochondrial lifespan is also related to lifespan.
It is interesting that although the vast majority of proteins found in mitochondria are encoded by the nuclear genome, mitochondria have their own unique translation mechanism and genome, previously believed to encode only 13 proteins.
In the past decade, the number of identified mitochondrial derived peptides (MDP) and micropeptides has increased exponentially. The Humanin peptide is the first member of this novel mitochondrial derived signaling peptide, which now includes MOTS-c and SHLP1-6.
Humanin peptides were initially discovered in screening for proteins that protect against Alzheimer's disease (AD). Since its initial discovery, Humanin peptides have played a role in preventing many other age-related diseases, such as atherosclerosis and stroke
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