| Purity: | 99.99 |
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| Powder Raw: | Yes |
| Concealed Transportation: | Yes |
| Freight Timeliness: | 10-15days |
| Transport Package: | Covert Disguise |
| Specification: | 1mg-10mg |
| Samples: |
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| Customization: |
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MOTS‐c is a peptide of 16 amino acids expressed by a mitochondrial gene. Research provides evidence that mitochondria play a key role in signaling and in energy production.
MOTS-c regulates metabolic functions throughout the body, including turning glucose into usable energy. Preliminary studies show evidence for improved control over blood sugar levels for those with type 2 diabetes and obesity.
Research also shows that skeletal muscle is the major target tissue of MOTS‐c. The skeletal muscle enhances sensitivity and increases glucose uptake in myocytes (muscle cells) by activating the pathway and at the same time without increasing . It is fair to call MOTS‐c an exercise‐mimetic, meaning it imitates exercise on the body. Exercise also increases muscle glucose uptake without stimulating .
(AMP‐activated protein kinase), was identified in 1999 as the master switch for metabolism and the central regulator of both glucose and lipid (fat) metabolism. Since then it has been a target for therapeutic intervention against metabolic conditions such as type‐2 diabetes.
Metabolic flexibility is when our metabolism can efficiently switch and change when metabolic demand or supply is needed. These types of changes have trained our body to manage energy metabolism for optimal substrate (glucose, fatty acids, amino acids) storage and use during states of either food excess or deficiency, and periods of either rest or increased energy demand.
The human body knows how to use moderate amounts of carbohydrates, amino acids and fatty acids. Our western diet, however, is characterized by excess food supply. Metabolic dysfunction or metabolic inflexibility is caused by continuous intake of excess calories, processed foods, and physical inactivity.
In various models of obesity and diabetes we know that some metabolic pathways are dysfunctional. It is caused by competition between sugars, fats and proteins and what we call the 3 prongs of metabolic insensitivity.
Excess calories can overwhelm the mitochondria and cause mitochondrial dysfunction.
This has many detrimental effects on metabolism and is strongly associated with weight gain in both humans and animal models.
A functional metabolism needs proper glucose and regulation, proper energy consumption and usage, and optimal mitochondria functioning. Other factors can contribute as well but the more we learn the more we are understanding that the mitochondria may actively regulate metabolic homeostasis at the cellular level. Could we then propose this equation, fix the mitochondria = fix the metabolism?
We know that mitochondria are the main cellular sites devoted to ATP (energy) production and fatty acid oxidation. The Mitochondrial-Derived Peptide MOTS-c promotes metabolic homeostasis and reduces obesity and resistance. Mitochondria also play a crucial role in determining metabolic flexibility.
Osteoporosis is a multi-factor and age-related metabolic disease. Bone mesenchymal stem cells (BMSCs) are the progenitor cells of osteoblasts and adipocytes and play an essential role in the process of bone formation.
can stimulate the proliferation, differentiation and mineralization of osteoblasts, which exerts an important role in the cellular functions of osteoblasts. Osteoblasts are cells that make bone. Bone mass is maintained by a balance between the activity of osteoblasts that form bone and other cells called osteoclasts that break it down.
Studies show that BMSC's treated with MOTS-c upregulated expression levels of ALP, Bglap, and Runx2. This resulted in the formation of mineralized nodules, indicating the osteogenic capacity of BMSC's regulated by MOTS-c. In simple nonscientific terms,
MOTS-c promotes cell differentiation of BMSCs to osteoblasts = bone formation.
Q1: About the after-sale service of products
A: After purchasing the products from our factory, we have A professional technical team and after-sales team to serve you and solve all your problems in the future
Q2: Can I get some samples?
A: Yes, we can provide samples, but the customer will pay the freight.
Q3: How do I start paying?
Payment can be made by Bitcoin,wire transfer or Western Union or paypal
Q4: How to confirm product quality before placing an order?
A: You can get free samples of some products. You just have to pay the shipping fee or arrange for the sample to be sent to us by express.
You can send us your product specifications and requirements and we will produce products according to your requirements.
Q5: What is your MOQ?
A: The minimum quantity we can order is 1kg.
But usually we can accept a smaller quantity, say 100g, at the cost of 100% sample charge.
Q6: Shipping Time?
A: We ship the parcel out in 3-7 days and offer tracking No.. Shipping time is different to different country. Please consult.
Welcome to be our distinguished customer, please do not hesitate to contact us!
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