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2. The role of P21 gene in cell apoptosis.
After DNA damage, the increase in P53 protein levels will lead to a variety of downstream events, including cell cycle arrest, DNA repair or differentiation, and cell apoptosis. P53 protein activates the expression of P21 gene, allowing it to inhibit the cell cycle, repair damaged DNA, and mediate the apoptosis of cells that fail to repair DNA. Therefore, in the P53-dependent pathway, P21 gene indirectly participates in cell apoptosis through the effect of cell cycle arrest, but it is not an essential factor in the process of cell apoptosis. In addition, studies have shown that Myc gene can regulate the role of P21 gene in cell apoptosis. Soane[2] believes that Myc does not affect the binding of P53 protein to P21 gene, but can selectively inhibit the activation of P53 on P21 gene, thereby reducing the expression of P21, which is beneficial to P53-mediated cell apoptosis.
3. The role of P21 gene in cell differentiation
Cell cycle arrest is a prerequisite for cell differentiation, so P21 is also closely related to cell differentiation. P21 gene is an important component of the negative regulatory loop of cell differentiation. In the terminal stage of cell differentiation, P21 must be inactivated to ensure the normal progress of differentiation [3]. Other studies have confirmed that when the full length or carboxyl terminal part of the P21 gene is expressed, differentiation inhibition can occur, and the functional domain related to cell cycle arrest is mainly located at the amino terminal. This shows that the effect of P21 on differentiation inhibition is not a subsidiary effect of cell cycle arrest, but may occur through other pathways. P21, as an inducible growth inhibitor, causes cells to break away from the cell cycle and differentiate, which is of great significance in the process of individual development.
The impact of genes on the occurrence of diseases
Studies have shown that the polymorphism of the P21 gene is closely related to the incidence of cervical cancer. The protein encoded by the P21 gene plays a key role in the P53-mediated G1 phase block of the cervical cell cycle. When DNA is damaged, P53 expression increases, thereby inducing P21 expression. P21 is a negative regulator of the cervical cell cycle. Increased P21 levels can cause cervical cells to remain in the G1 phase, waiting for DNA repair or entering the apoptosis pathway. This mechanism helps prevent the accumulation of DNA damage and the malignant transformation of cells. Therefore, P21 plays an important role in the occurrence of cervical cancer.
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Q2: Can I get some samples?
A: Yes, we can provide samples, but the customer will pay the freight.
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A: You can get free samples of some products. You just have to pay the shipping fee or arrange for the sample to be sent to us by express.
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Q5: What is your MOQ?
A: The minimum quantity we can order is 1kg.
But usually we can accept a smaller quantity, say 100g, at the cost of 100% sample charge.
Q6: Shipping Time?
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